Gene mutation produces autism-like traits in mice

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Gene mutation produces autism-like traits in mice

Wednesday, March 23, 2011

By causing the mutation of one specific gene, researchers have produced mice with two frequently encountered behavioral traits of persons diagnosed with autism. Autism commonly affects the ability to interact socially and is associated with repetitive behavior. The finding was reported in the March 20 online edition of Nature.

Using mice, researchers at the Massachusetts Institute of Technology (MIT) and Duke University mutated one of the genes associated with autism, known as shank3, a gene that controls the production of the shank3 protein present in the brain. Mice that were given this mutation exhibited repetitive behavior and avoided social interactions with the mice around them.

According to MIT Professor Guoping Feng: “Our study demonstrated that Shank3 mutation in mice lead to defects in neuron-neuron communications.”

Shank3 protein are found in synapses within the brain. Synapses allow brain cells (called neurons) to communicate with each other. The mutation in the mouse gene interfered with this communication, apparently producing the subsequent autism-like traits. Researchers believe their work demonstrates the important role of shank3 in the functioning of brain circuits that determine behavior.

While hundreds of genes have been linked to autism in human patients, only a small percentage have been linked to shank3. Professor Feng hypothesizes that disruptions of other genes that act on the production of brain proteins affecting synaptic communication may also be related to autistic behavior. If this disruption is real, Feng claims that treatments could be developed to correct synaptic function for any defective synaptic protein in an autistic patient.

Feng continued; “These findings and the mouse model now allow us to figure out the precise neural circuit defects responsible for these abnormal behaviours, which could lead to novel strategies and targets for developing treatment.”

About one in 110 children in the U.S., and at least one in 100 in UK, have been diagnosed with an autism spectrum disorder, for which there is currently no effective cure.

Retrieved from “https://en.wikinews.org/w/index.php?title=Gene_mutation_produces_autism-like_traits_in_mice&oldid=4050983”

Wikinews interviews candidate for Cleveland mayor Arthur Kostendt

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Wikinews interviews candidate for Cleveland mayor Arthur Kostendt

Monday, June 14, 2021

Arthur Oliver Kostendt, a candidate running in the mayoral election of the US city of Cleveland, Ohio set to take place November 2, discussed his campaign and policies with Wikinews this spring.

According to Cleveland Scene, 29-year-old Kostendt is a member of the Cuyahoga County, Ohio Republican Party but has referred to his campaign as “casual”. According to his web site’s personal biography, he was a cadet for the Army Reserve Officers’ Training Corps (ROTC), scout platoon leader for the 2nd Squadron of the 107th Cavalry Regiment of the Ohio Army National Guard and logistics officer for the 1st Battalion of the 145th Armored Regiment. He served in Kuwait, Iraq, the United Arab Emirates and Saudi Arabia and assisted coalition force detachments in Southeast Asia.

Kostendt is a graduate of the University of Notre Dame and summa cum laude graduate of Cleveland State University. He writes he uses an apostrophe to abbreviate his middle name as “Arthur O’Kostendt” instead of the customary period after the O to emphasise his Irish heritage.

A poll published May 5 by Baldwin Wallace University, which does not feature Mr Kostendt, has Dennis Kucinich and Basheer Jones leading in the mayoral race by 17.8 and 13.3 points, respectively, with a margin of error of up to five per cent either way. 48% of those surveyed were undecided. Incumbent mayor Frank G. Jackson, who won the 2017 Cleveland mayoral election with 59% of the vote, is eligible for a fifth term but announced on May 6 he would retire.

Retrieved from “https://en.wikinews.org/w/index.php?title=Wikinews_interviews_candidate_for_Cleveland_mayor_Arthur_Kostendt&oldid=4626048”

Outsourced Accounting Services

Outsourced Accounting Services

by

orionshell

The word ‘outsource’ literally means hiring or engaging others to do your work effectively. If you want to stay tune to the competition, it is necessary to outsource certain things for better management ideas. Many companies have outsourced accounting and auditing to private parties so that they can concentrate on other major tasks of the organization.

[youtube]http://www.youtube.com/watch?v=C2dccEZaaF4[/youtube]

There are thousands of such accounting firms which offer professional service for reasonable cost. By hiring one of such companies, you can save considerable time which would otherwise be spent on the hassle of checking the accounts and balancing the sheet. The accounting firms are very dedicated in providing accurate service for their clients. They can stay in the market only if they offer continuous and timely service subject to the satisfaction of the client. The duties of the accounting firm include preparation of accounts annually and settling disputes of auditing, preparation of salary bill for the entire staff of the company and other pay roll service. Further outsourcing the accounts will free you from the hassle of filing returns annually. They would take care of filing income tax and sales tax return and even render help to the clients in the recovery of debts. They would also keep you updated with the future cash requirements in advance so that you are given sufficient time to make arrangement. Now some companies are handling their accounts efficiently with automation facility. But the desired output cannot be reached if there is complete automation. Sometimes these automated systems will not be able to match the needs of the company and again you are forced to do the method of standard accounting process by hand. To avoid this you can directly outsource the work of accounting to reputable companies and accountants who are expert in handling them. Initially the accounting firm would analyze the needs of your company making their service customer centric or highly customized. It is the duty of the accounting firm to provide timely service with well informed decisions about various aspects of accounts and handling cash. You can find out the best firm by doing analysis on the internet or alternatively you can ask opinion from similar companies like yours. Do not go for the company which offers outsourced accounting service for cheap rates since the very purpose of outsourcing will not be met. The firm you hire should be efficient and experience enough to handle the complete accounts of you and your company. The outsourcing has become trend for many organizations not only for accounts purpose but also for various other internal purposes like marketing their product etc. This conent has been taken from http://www.ideamarketers.com/?articleid=3236369&CFID=176195403&CFTOKEN=61267455

Mature yet progressive firm, DKS&S is dedicated to clients like you who want to grow their companies and accumulate personal net worth and

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and business advisors work closely with your team,coaching your company to prosperity,success and productivity.

Article Source:

ArticleRich.com

Possibility of new graphic health warnings on NZ cigarette packs

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Possibility of new graphic health warnings on NZ cigarette packs

Wednesday, May 10, 2006

New Zealand Associate Minister of Health Damien O’Connor has proposed that warnings, both images and text, should cover 60% of the packaging of cigarettes sold in the country. New Zealand is required to do so under obligations to the World Health Organisation.

The new images would depict throat cancer, rotting teeth/gums and gangrenous feet. Ashley Bloomfield, Chief Advisor on Public Health, says written warnings aren’t as effective as pictures, and that many smokers do not know most of the diseases that smoking can cause.

If the proposal were adopted, the Ministry would dictate the size and placement of the images to the tobacco companies, but would not subsidise the cost of the changes.

Retrieved from “https://en.wikinews.org/w/index.php?title=Possibility_of_new_graphic_health_warnings_on_NZ_cigarette_packs&oldid=1950739”

Category:Food

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Category:Food
October 10th, 2022 in Uncategorized | No Comments

This is the category for food.

Refresh this list to see the latest articles.

  • 14 April 2017: Google blocks home device from responding to Burger King commercial
  • 1 January 2017: William Salice, creator of Kinder Surprise eggs, dies at 83
  • 3 December 2016: Chinese chef Peng Chang-kuei’s death announced
  • 5 October 2016: World Wildlife Fund: 75% of seafood species consumed in Singapore not caught sustainably
  • 14 September 2016: Scientists claim decrease in hotness of Bhut Jolokia
  • 17 October 2015: Police shut down Edmonton pizza restaurant for illegally delivering alcohol
  • 16 September 2015: Subway sandwich empire co-founder Fred DeLuca dies
  • 30 August 2013: UK beer, soft drinks delivery drivers vote to strike
  • 7 August 2013: Russian government homosexuality position leads to NYC Russian vodka boycott
  • 12 May 2013: Fifth Expo Gastronomía finishes in Caracas
?Category:Food

From Wikinews, the free news source you can write.



Sister projects
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Subcategories

Pages in category “Food”

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Australian health workers to close intensive care units in Victoria next week

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Australian health workers to close intensive care units in Victoria next week
October 9th, 2022 in Uncategorized | No Comments

Thursday, March 13, 2008

Members of Australia’s Health Services Union (HSU) will go on strike in Victoria next week in a dispute over stalled wage and career structure negotiations. Over 5000 physiotherapists, speech pathologists and radiation therapists will walk off the job next week, effectively closing the state’s 68 largest health services.

The strike will force the closure of intensive care units and emergency departments across the state.

It is feared the strike could continue into Easter.

National secretary of the HSU, Kathy Jackson said admissions would be crippled, while intensive care patients would have to be evacuated to New South Wales, Tasmania and South Australia as hospitals will not be able to perform tests or administer treatment.

“When an ambulance shows up you can’t admit a patient without an X-ray being available, you can’t intubate them and you can’t operate on them,” she said.

“If something goes wrong in an ICU you need to be able to X-ray, use nuclear medicine or any diagnostic procedure,” said Ms Jackson.

Ms Jackson said the HSU offered arbitration last year, but the state government refused. “They’re not interested in settling disputes, they hope that we are just going to go away.”

“We’re not going away, we’ve gone back and balloted the whole public health workforce in Victoria, those ballots were successful, 97 percent approval rating,” she said.

The HSU is urging the government to commence serious negotiations to resolve the dispute before industrial action commenced.

The government has offered the union a 3.25 per cent pay increase, in line with other public sector workers but the union has demanded more, but stopped short of specifying a figure.

Victorian Premier John Brumby said the claim would be settled according to the government’s wages policy. “The Government is always willing and wanting to sit down and negotiate with the relevant organisations . . . we have a wages policy based around an increase of 3.25 per cent and, above that, productivity offset,” he told parliament.

The union claims it is also arguing against a lack of career structure, which has caused many professionals to leave the health service. Ms Jackson said wages and career structures in Victoria were behind other states.

Victorian Opposition Leader Ted Baillieu said he was not in support of the proposed strike and called on the government to meet with unions. “There could not be a more serious threat to our health system than has been announced today.”

“We now have to do whatever is possible to stop this strike from proceeding,” he said.

The opposition leader will meet with the union at 11:30 AM today.

Victorian Hospitals Industry Association industrial relations services manager Simon Chant said hospitals were looking at the possible impact and warned that patients may have to be evacuated interstate if the strike goes ahead.

Retrieved from “https://en.wikinews.org/w/index.php?title=Australian_health_workers_to_close_intensive_care_units_in_Victoria_next_week&oldid=4360153”

Air Conditioner Buying Tips

October 8th, 2022 in Workshop And Engineering Equipment | No Comments

By Gray Rollins

Most new homes today have air conditioning units. It is more unusual to see homes without central air then to see ones with it nowadays. Air conditioning can be a necessity in warmer climates for the comfort of the family. Most air conditioner units will range from three to six thousand dollars, including installation. This is not a minor investment but one necessary for comfort. If you need a new air conditioner, there are several things to consider prior to purchasing.

Air conditioning units should be installed by a contractor who is experienced with this type of work. Depending on existing ducts and the type of unit purchased, the price may vary greatly. Get several estimates from qualified contractors before deciding on the unit and installer. Ensure the contractor has experience and works well with you. Get references and check them thoroughly.

Air conditioner units use electricity to run. If the unit is used often this can increase energy costs significantly. This is especially true in warmer climates where it is a necessity to cool the home. To help combat these costs, it is advisable to look at the efficiency of the unit. This may mean a larger initial investment, but should save money in the long run.

[youtube]http://www.youtube.com/watch?v=RSwXKDg4hVg[/youtube]

The efficiency rating is required to be on all air conditioners. Compare units carefully to determine the cost for each type of efficiency. The more efficient a unit is, the more money you will save on energy bills. A more efficient air conditioner will take less energy to run and cool the entire house.

You will need to determine the appropriate size of the unit needed for your house. This is an important step because units that are too small will have to work harder to cool the home. Units that are too large are simply wasteful and unnecessary. A qualified air conditioner contractor will be able to analyze the size of your home and make recommendations on the size needed.

Always get a contract before starting work with any contractor. Make sure all the costs are clearly spelled out. This should include both the cost of the unit and installation. It should also detail payment policies and warranties. Warranties generally cover the compressor and additional parts. Do not choose a unit that has anything less than a five year warranty on the compressor, but a ten year warranty is better. Additional parts may be warranted anywhere from one to five years and are usually separate.

About the Author: Gray Rollins is a featured writer for AirConditioningZone.com. To learn more about

central air

and

air conditioner installation

, visit us.

Source:

isnare.com

Permanent Link:

isnare.com/?aid=38354&ca=Home+Management

Bucharest to be ‘rebranded’ for 800 million euro

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Bucharest to be ‘rebranded’ for 800 million euro
October 7th, 2022 in Uncategorized | No Comments

Wednesday, March 2, 2005

Bucharest, Romania — The city centre of Bucharest, the capital of Romania, is set to get a major facelift due to a real estate project called Esplanada (The Esplanade), which will be constructed by TriGranit Development Corporation. The total investment in the project will be greater than 800 million euro and aims to build a modern commercial pedestrian area in downtown Bucharest, with several shopping malls, office buildings, hotels and dwellings. It will be the largest real estate program in Romania since the fall of Communism in 1989.

Bucharest is currently looking at possibilities to improve its appearance and rebrand itself as a lively, creative and vibrant city. Many initiatives have sprung up to improve the city, including the organisation of CowParade later this year. Additionally, the old town centre will be restored. Due to Romania’s current economic boom, several other major construction projects are taking place.

Bucharest City Hall has blocked traffic in the city center due both to the old town restoration and to the Esplanada project.

Retrieved from “https://en.wikinews.org/w/index.php?title=Bucharest_to_be_%27rebranded%27_for_800_million_euro&oldid=715662”

Dell would be ‘happy’ to sell PCs running Mac OS X

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Dell would be ‘happy’ to sell PCs running Mac OS X
October 5th, 2022 in Uncategorized | No Comments

Friday, June 17, 2005

PC manufacturer and Apple Computer competitor Dell, Inc. has stated that it is interested in shipping computers running Apple’s Mac OS X. Michael Dell, founder and chairman of Dell Computers, made the comments while talking to David Kirkpatrick of Fortune magazine.

“If Apple decides to open the Mac OS to others, we would be happy to offer it to our customers,” Dell wrote in an email to Kirkpatrick. Apple recently announced that it would begin using Intel x86 microprocessors in its computers next year, but has continued to deny reports that they will allow their OS to be run on non-Apple hardware.

Retrieved from “https://en.wikinews.org/w/index.php?title=Dell_would_be_%27happy%27_to_sell_PCs_running_Mac_OS_X&oldid=979449”

17 million accounts’ hashed passwords, emails stolen, Zomato says

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17 million accounts’ hashed passwords, emails stolen, Zomato says
October 4th, 2022 in Uncategorized | No Comments

Friday, May 19, 2017

Yesterday, Zomato, a food ordering and restaurant finding company, announced security breach of more than 17 million accounts, via their official blog. A hacker operating under the alias nclay uploaded evidence to prove they had the stolen data — hashed passwords and emails — for sale, Hackread.com reported. Zomato later announced they contacted the hacker, who asked Zomato to organise a bug bounty programme.

The food ordering company, with 120 million monthly users, said the payment information of the users was not located with this data and was not leaked. Zomato said it uses PCI Data Security Standards.

As a security measure, all the passwords of the involved Zomato accounts were reset and all of the accounts were forcibly logged out from the application and website. The company said only hashed passwords were compromised.

Hashed passwords are encrypted and, per Zomato, every password had a different “salt”, for cryptographic salting was performed before hashing the original password. A “salt” is a random set of characters added before encryption to make decryption to obtain the original passkey more difficult.

The hashed password itself can not be used to access the account. In the blog post before contacting the hacker, saying “internal (human) security breach”, Zomato suggested this could have happened after a worker’s development account was hijacked. After contacting the hacker, and promising a bug bounty programme on Hackerone, they said, the hacker agreed and removed the stolen data which was put on sale on the dark web. Zomato said they are looking forward to working closely with the ethical hacker community on security vulnerabilities.

Retrieved from “https://en.wikinews.org/w/index.php?title=17_million_accounts%27_hashed_passwords,_emails_stolen,_Zomato_says&oldid=4344743”